Getting a Transcription Factor to Only One Nucleus Following Mitosis

Getting a Transcription Factor to Only One Nucleus Following Mitosis

Primer T he growth and development of all eukaryotes depends on the process of asymmetric cell division, in which a single cell gives rise to two genetically identical cells that adopt distinct fates [1,2]. Asymmetry occurs when two cells are exposed to different environmental stimuli or when specific mRNAs or proteins (known as cell fate determinants) are segregated unequally. In recent years,...

Getting In and Out of Mitosis*

A series of preparatory steps must take place before a cell enters mitosis, and these steps must be undone to exit mitosis. The cell has a nucleus which contains the genetic material, the DNA, as chromosomes packaged with proteins. Before the cell undergoes mitosis, the cell must make two copies of its DNA so that each daughter cell has a complete copy of the genetic material. At the onset of m...

Only one way to skin a mouse

Actin (green) and ADF/cofilin (red) are disorganized in the absence of tropomyosin (bottom). ntracellular parasites must walk a fine line, invading and exploiting a host cell without killing it too quickly. On page 1029, Glomski et al. show how a single amino acid determines not only the pH I optimum of a bacterial hemolysin, but also the virulence of an important pathogen. The data help explai...

Only one way to organize a movement?

The needs of the pore ccording to a model that has prevailed since the early 1990s, nuclear import complexes need to dock to the cytoplasmic filaments of the nuclear pore complex (NPC) before they can be translocated to the nucleus. On page 63, Walther et al. A overturn this idea, demonstrating that cytoplasmic filaments have no essential function in the nuclear import of bulk cargos. The resul...

metabolic syndrome and mitochondrial transcription factor a